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Prof. Hussein Mohammed was born over six decades ago to the Mohammed family of Afoko quarters, Imiokono-Jagbe, Etsako-West Local Government of Edo State, Nigeria. He started his Primary Education at Ansarudeen Primary School, Owo in 1963. On the creation of Mid-West Region, his parents moved, and he thereafter attended several primary schools in the region and concluded his Primary Education at Nigerian Batist Convention N.B.C.) primary School, Sapele in 1969. He was at Immaculate Conception College (ICC) Benin City, between 1970 and 1974, where he obtained his West African School Certificate; and at Auchi Polytechnic, Auchi, in 1975 where he obtained his Ordinary National Diploma (OND) in Civil Engineering/Building in 1977.

He was admitted into the then University of Ife (now Obafemi Awolowo University) to the Civil Engineering programme. He graduated from the University in 1982 with a good Honours degree. He had his M.Sc. degree in 2004, and a Doctor of Philosophy degree (PhD) of the University of Ibadan in 2010. He was elected a member of the Nigerian Society of Engineers (NSE) in March, 1989 and registered by the council for the Registration of Engineers in Nigeria (COREN), in July, 1990. He had the National Youth Service in 1982-1983 as an Engineer with an indigenous Engineering and Construction Company, O.V. General Contractors.

He moved to the Capital Project Unit, Obafemi Awolowo University, Ile-Ife in 1983 as a Resident Engineer and voluntarily withdrew his services from the University to take up the job of pioneer Managing Director of Capnice Engineering and Construction Company Limited, Lagos and held this position for ten years. He has served as Associate Consultant to Rafola Ayibiowu Engineering Limited, Amana Consortium Limited, Delkem Associates, amongst others. In 2006, Polytran Engineering Associates appointed him as the Project Manager, for the Akwa-Ibom International Airport.

He taught briefly at Lagos State University, Epe in the Department of Mechanical Engineering. He rejoined Obafemi Awolowo University, Ile-Ife, in 2010 as a Lecturer Grade I in the Department of Civil Engineering. He attained the rank of a Senior Lecturer in 2014, Reader in 2018 and Professor, in 2021. Prof. Mohammed has published articles in reputable peer-reviewed Local and International Scientific and Engineering Journals in addition to technical reports. He has attended Conferences/Seminars in engineering, nationally and internationally. He serves as an external examiner to local and foreign universities as well as reviewer to local and international journals. Prof. Mohammed is married to Barr. Dr. Jade Mohammed ((nee Adelakun) and they are blessed with children.